Literature summary for 3.6.5.1 extracted from

Smith, B.; Hill, C.; Godfrey, E.L.; Rand, D.; van den Berg, H.; Thornton, S.; Hodgkin, M.; Davey, J.; Ladds, G.
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis (2009), Cell. Signal., 21, 1151-1160.

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Activating Compound

Activating Compound	Comment	Organism	Structure
regulator of G protein signaling protein	Gpa1 signaling potentiated by high stimulation	Saccharomyces pombe

Protein Variants

Protein Variants	Comment	Organism
G223S	blocked interaction with regulator of G-protein signaling protein	Saccharomyces pombe
Q244L	decreased GTPase activity	Saccharomyces pombe

Inhibitors

Inhibitors	Comment	Organism	Structure
regulator of G protein signaling protein	Gpa1 signaling suppressed by low stimulation	Saccharomyces pombe

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces pombe	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Saccharomyces pombe	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Galpha-subunit	-	Saccharomyces pombe
GPA1	-	Saccharomyces pombe
heterotrimeric G protein	-	Saccharomyces pombe

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Release 2023.1 (January 2023)