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Literature summary for 3.6.5.1 extracted from
- Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant-negative, G-protein alpha-subunit (2006), Mol. Vis., 12, 492-498.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| RGS16 protein | - |
Homo sapiens | |
| RGS9d protein | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | mutants of transducin represent a major tool in designing potential therapeutical strategies for a group of visual diseases | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Gtalpha and GtalphaR238E for expression in Escherichia coli strains DH5alpha and BL21(DE3) | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R238E | mutant, reported to be a dominant-negative inhibitor of the rhodopsin-transducin-PDE visual system | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| outer membrane | outer rod segment membrane | Homo sapiens | 19867 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using Ni-NTA His-binding affinity chromatography and a Mono Q column | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retinal rod | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotrimer | Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GTP phosphohydrolase | - |
Homo sapiens |
| heterotrimeric G-protein GTPase | - |
Homo sapiens |
| transducin | - |
Homo sapiens |
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