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Literature summary for 3.6.5.1 extracted from
- Endogenous regulator of G-protein signaling proteins regulate the kinetics of Galphaq/11-mediated modulation of ion channels in central nervous system neurons (2006), Mol. Pharmacol., 69, 1280-1287.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| RGS | regulator of G-protein signaling | Rattus norvegicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Rattus norvegicus |
| Galpha subunit is subcloned into pcDNA3.1+ | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Rattus norvegicus | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | cerebellar granule neuron | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Rattus norvegicus | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotrimer | Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GTP phosphohydrolase | - |
Rattus norvegicus |
| heterotrimeric G-protein GTPase | - |
Rattus norvegicus |
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