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Literature summary for 3.6.5.1 extracted from

  • Sauvage, C.; Rumigny, J.F.; Maitre, M.
    Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation (1991), Mol. Cell. Biochem., 107, 65-77.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
GTP G36 protein, unmodified Homo sapiens
0.85
-
GTP G36 protein phosphorylated by protein kinase M-like kinase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification protein kinase K-like kinase phosphorylates G36 protein. The phosphorylation of G36 increases its Km for GTP by about 8fold without modification of Vmax. No significant modification after phosphorylation of G50 by protein kinase C or cAMP kinase Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Homo sapiens GDP + phosphate
-
?

Subunits

Subunits Comment Organism
More G36 with a MW of 36000 Da determined by SDS-PAGE can be Gialpha or Goalpha. G50 with a MW of 50000 Da determined by SDS-PAGE can be Gsalpha Homo sapiens