Literature summary for 3.6.5.1 extracted from

Wise, A.; Watson-Koken, M.A.; Rees, S.; Lee, M.; Milligan, G.
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants (1997), Biochem. J., 321, 721-728.

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Protein Variants

Protein Variants	Comment	Organism
C351G	mutation of Gi1alpha or Gi3alpha, pertussis toxin-resistant mutant	Rattus norvegicus
C352G	mutation of Gi2alpha, pertussis toxin-resistant mutant	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
pertussis toxin	pertussis toxin-catalysed ADP-ribosylation prevents functional contacts between G-protein-coupled receptors and the Gi-like G-proteins	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Rattus norvegicus	Gi1alpha, Gi2alpha and Gi3alpha are capable of preventing stimulation of adenylate cyclase by the alpha2A-adrenoceptor	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Gi1alpha, Gi2alpha anf Gi3alpha	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	Gi1alpha, Gi2alpha and Gi3alpha are capable of preventing stimulation of adenylate cyclase by the alpha2A-adrenoceptor	Rattus norvegicus	GDP + phosphate	-	?

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Release 2023.1 (January 2023)