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Literature summary for 3.6.4.13 extracted from

  • Booy, E.P.; Meier, M.; Okun, N.; Novakowski, S.K.; Xiong, S.; Stetefeld, J.; McKenna, S.A.
    The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary (2012), Nucleic Acids Res., 40, 4110-4124.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
DELTA53-105 a region within the N-terminus of RHAU, referred to as the RSM, interacts with human telomerase RNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens human telomerase RNA interacts with the N-terminal domain of RHAU ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Homo sapiens ADP + phosphate
-
?
additional information human telomerase RNA interacts with the N-terminal domain of RHAU Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DHX36
-
Homo sapiens
RNA helicase RHAU
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction RHAU knockdown by small interfering RNA (siRNA) results in a significant reduction in average telomere lengths supporting an impact of RHAU on telomerase function Homo sapiens