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Literature summary for 3.6.4.10 extracted from

  • Blond-Elguindi, S.; Fourie, A.M.; Sambrook, J.F.; Gething, M.J.H.
    Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers (1993), J. Biol. Chem., 268, 12730-12735.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
pT7-mBiP containing the cDNA sequence encoding mature mouse BiP cloned and expressed in Escherichia coli BL21 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
ATP
-
Mus musculus
0.67
-
ATP
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol hsc70 Bos taurus 5829
-
endoplasmic reticulum Hsp70 Bos taurus 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
1 * 44000 + 1 * 30000 Bos taurus
44000
-
1 * 44000 + 1 * 30000 Bos taurus
70000
-
-
Bos taurus
78000
-
grp78/BiP Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Cricetulus griseus
-
ADP + phosphate
-
?
ATP + H2O Mus musculus
-
ADP + phosphate
-
?
ATP + H2O Bos taurus
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cricetulus griseus
-
chinese hamster
-
Mus musculus
-
mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus
recombinant murine BiP, expressed in Escherichia coli Mus musculus

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Cricetulus griseus
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Mus musculus
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Cricetulus griseus ADP + phosphate
-
?
ATP + H2O
-
Mus musculus ADP + phosphate
-
?
ATP + H2O
-
Bos taurus ADP + phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 44000 + 1 * 30000 Bos taurus

Synonyms

Synonyms Comment Organism
BiP
-
Cricetulus griseus
BiP
-
Bos taurus
Grp78
-
Cricetulus griseus
Grp78
-
Bos taurus
Hsp70
-
Bos taurus
molecular chaperone BiP
-
Bos taurus