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Literature summary for 3.6.1.27 extracted from

  • Stone, K.J.; Strominger, J.L.
    Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate (1971), Proc. Natl. Acad. Sci. USA, 68, 3223-3227.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bacitracin complex formation with substrate + metal ion, reversed by addition of chelating agents Enterococcus faecalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Enterococcus faecalis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enhances inhibitory effect of bacitacin Enterococcus faecalis
Cd2+ enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin Enterococcus faecalis
Co2+ enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin Enterococcus faecalis
Cu2+ enhances inhibitory effect of bacitacin Enterococcus faecalis
Fe2+ enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin Enterococcus faecalis
Mg2+ enhances inhibitory effect of bacitacin Enterococcus faecalis
Mn2+ enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin Enterococcus faecalis
additional information no requirement for added metal ions Enterococcus faecalis
Zn2+ enhances inhibitory effect of bacitacin Enterococcus faecalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
undecaprenyl diphosphate + H2O Enterococcus faecalis involved in cyclic peptidoglycan pathway undecaprenyl phosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
undecaprenyl diphosphate + H2O
-
Enterococcus faecalis undecaprenyl phosphate + phosphate
-
?
undecaprenyl diphosphate + H2O involved in cyclic peptidoglycan pathway Enterococcus faecalis undecaprenyl phosphate + phosphate
-
?