Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the short isoform of dUTPase (NTT-DUT) remains exclusively in the cytoplasm | Drosophila melanogaster | 5737 | - |
nucleus | the long isoform of dUTPase (LD-DUT) is specifically targeted into the nucleus | Drosophila melanogaster | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63000 | - |
N-terminally truncated short isoform NTT-DUT | Drosophila melanogaster |
69000 | - |
long isoform LD-DUT | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9V3I1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | - |
Drosophila melanogaster | dUMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotrimer | - |
Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
dUTPase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of dUTPase leads to uracil-substituted DNA that perturbs base excision repair, resulting in DNA fragmentation and thymine-less cell death | Drosophila melanogaster |
physiological function | dUTPase is responsible for prevention of uracil incorporation into DNA | Drosophila melanogaster |