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Literature summary for 3.6.1.23 extracted from

  • Kawahara, A.; Akagi, Y.; Hattori, S.; Mizobe, T.; Shirouzu, K.; Ono, M.; Yanagawa, T.; Kuwano, M.; Kage, M.
    Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer (2009), J. Clin. Pathol., 62, 364-369.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Homo sapiens
-
dUMP + diphosphate
-
?
additional information Homo sapiens the enzyme limits the activation or degradation of 5-fluorouracil, overview. The expression of dUTPase is significantly different between primary tumours and their corresponding metastatic tumour ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell primary cancer, patients after surgery, expression levels of the enzyme in the primary colorectal cancer of patients with and without distant metastases, the expression level is 3fold higher in the first case, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
Homo sapiens dUMP + diphosphate
-
?
additional information the enzyme limits the activation or degradation of 5-fluorouracil, overview. The expression of dUTPase is significantly different between primary tumours and their corresponding metastatic tumour Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
deoxyuridine triphosphatase
-
Homo sapiens
dUTPase
-
Homo sapiens