Literature summary for 3.6.1.23 extracted from

Guillet, M.; Van Der Kemp, P.A.; Boiteux, S.
dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae (2006), Nucleic Acids Res., 34, 2056-2066.

Search for more literature for 3.6.1.23

Cloned(Commentary)

Cloned (Comment)	Organism
gene DUT1, DNA and amino acid sequence determination and analysis of DUT1 alleles, genotyping, expression of wild-type and mutant enzymes in yeast strains	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
G82S	allele dut1-1 of gene dut1 possesses a single amino acid substitution in a conserved motif nearby the active site and exhibits a greatly reduced dUTPase activity, dut1-1 single mutant exhibits growth delay and cell cycle abnormalities and shows a strong spontaneous mutator phenotype, the dut1-1 allele is deleterious in wild-type strain and AP sites repair defective mutants, overview. The dut1-1 mutant is a spontaneous mutator that accumulates AT to CG transversions	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P33317	several strains, overview, gene DUT1	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant wild-type and mutant enzymes from yeast strains	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)