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Literature summary for 3.6.1.23 extracted from

  • Bekesi, A.; Zagyva, I.; Hunyadi-Gulyas, E.; Pongracz, V.; Kovari, J.; Nagy, A.O.; Erdei, A.; Medzihradszky, K.F.; Vertessy, B.G.
    Developmental regulation of dUTPase in Drosophila melanogaster (2004), J. Biol. Chem., 279, 22362-22370.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
two isozymes, DNA and amino acid sequence determination and analysis, developmental expression analysis, overview Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm one isozyme might be located in the cytoplasm Drosophila melanogaster 5737
-
additional information subcellular localization study, no localization of the enzyme in mitochondria Drosophila melanogaster
-
-
nucleus one isozyme might be located in the nucleus Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Drosophila melanogaster the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels dUMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
two isozymes
-

Purification (Commentary)

Purification (Comment) Organism
subcellular fractionation Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Drosophila melanogaster
-
larva reduced enzyme expression Drosophila melanogaster
-
additional information the enzyme is constitutively expressed in the adult fly Drosophila melanogaster
-
ovary
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
Drosophila melanogaster dUMP + diphosphate
-
?
dUTP + H2O the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels Drosophila melanogaster dUMP + diphosphate
-
?

Subunits

Subunits Comment Organism
More the enzyme interacts with several protein partners in the cell Drosophila melanogaster

Synonyms

Synonyms Comment Organism
dUTPase
-
Drosophila melanogaster