Cloned (Comment) | Organism |
---|---|
two isozymes, DNA and amino acid sequence determination and analysis, developmental expression analysis, overview | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | one isozyme might be located in the cytoplasm | Drosophila melanogaster | 5737 | - |
additional information | subcellular localization study, no localization of the enzyme in mitochondria | Drosophila melanogaster | - |
- |
nucleus | one isozyme might be located in the nucleus | Drosophila melanogaster | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | Drosophila melanogaster | the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels | dUMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
two isozymes | - |
Purification (Comment) | Organism |
---|---|
subcellular fractionation | Drosophila melanogaster |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Drosophila melanogaster | - |
larva | reduced enzyme expression | Drosophila melanogaster | - |
additional information | the enzyme is constitutively expressed in the adult fly | Drosophila melanogaster | - |
ovary | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | - |
Drosophila melanogaster | dUMP + diphosphate | - |
? | |
dUTP + H2O | the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels | Drosophila melanogaster | dUMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme interacts with several protein partners in the cell | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
dUTPase | - |
Drosophila melanogaster |