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Literature summary for 3.6.1.23 extracted from

  • Pardo, E.G.; Gutierrez, C
    Cell cycle-and differentiation stage-dependent variation of dUTPase activity in higher plant cells (1990), Exp. Cell Res., 186, 90-98.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-Aminouracil 5 mM, 50% loss of activity Allium cepa
6-aminouracil 5 mM, 60% loss of activity Allium cepa
EDTA 1 mM, 65% loss of activity Allium cepa
KCl 0.4 mM, 29% loss of activity Allium cepa
NEM 12 mM, 14% loss of activity Allium cepa
Uracil 5 mM, 30% loss of activity Allium cepa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
dUTP
-
Allium cepa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+, Mn2+ or Zn2+ required for enzyme function Allium cepa
Mn2+ Mg2+, Mn2+ or Zn2+ required for enzyme function Allium cepa
Zn2+ Mg2+, Mn2+ or Zn2+ required for enzyme function Allium cepa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
gel filtration Allium cepa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Allium cepa enzyme plays a key role in deoxyribonucleotide metabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Allium cepa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
root meristem cells, high levels of dUTPase in both resting and proliferating root meristem cells. Activity increase at the G1/S boundary, remains high throughout S phase, and shows almost undetectable levels during G1 and G2 Allium cepa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCTP + H2O no activity Allium cepa dCMP + diphosphate
-
?
dTTP + H2O no activity Allium cepa dTMP + diphosphate
-
?
dUTP + H2O
-
Allium cepa dUMP + diphosphate
-
?
dUTP + H2O enzyme plays a key role in deoxyribonucleotide metabolism Allium cepa ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
5 min, stable Allium cepa
45
-
5 min, 28% loss of activity Allium cepa
55
-
5 min, complete inactivation Allium cepa