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Literature summary for 3.6.1.23 extracted from

  • Ladner, R.D.; McNulty, D.E.; Carr, S.A.; Roberts, G.D.; Caradonna, S.J.
    Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase (1996), J. Biol. Chem., 271, 7745-7751.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
dUTP enzyme form DUT-N and DUT-M Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion enzyme form DUT-M Homo sapiens 5739
-
nucleus enzyme form DUT-N Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Homo sapiens enzyme is important in DNA replication ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P33316
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell enzyme form DUT-N is approximately 30fold more abundant in HeLa cells than in DUT-M cells Homo sapiens
-
HeLa-S3 cell
-
Homo sapiens
-
KB cell
-
Homo sapiens
-
RAJI cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
Homo sapiens dUMP + diphosphate
-
?
dUTP + H2O enzyme is important in DNA replication Homo sapiens ?
-
?