Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluoride | inhibition of Mg2+-dependent activity of ADP-ribose pyrophosphatase. the Mn2+-dependent activity is not affected by fluoride | Homo sapiens | |
Mn2+ | above 0.05 mM | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | marginally effective in activation | Homo sapiens | |
Mg2+ | strictly requires Mg2+ (more than 1 mM) or Mn2+ for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ | Homo sapiens | |
Mn2+ | strictly requires Mg2+ or Mn2+ (0.05 mM) for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ | Homo sapiens | |
Zn2+ | marginally effective in activation | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | 37000 | gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP-ribose + H2O | Homo sapiens | protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose | AMP + D-ribose 5-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP-ribose + H2O | - |
Homo sapiens | AMP + D-ribose 5-phosphate | - |
? | |
ADP-ribose + H2O | protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose | Homo sapiens | AMP + D-ribose 5-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NUDT9 protein | - |
Homo sapiens |
submicromolar-K(m) ADP-ribose pyrophosphatase | - |
Homo sapiens |