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Literature summary for 3.6.1.13 extracted from

  • Dunn, C.A.; OæHandley, S.F.; Frick, D.N.; Bessman, M.J.
    Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance (1999), J. Biol. Chem., 274, 32318-32324.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
-
Saccharomyces cerevisiae
-
Bacillus subtilis
-
Haemophilus influenzae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
ADPribose
-
Saccharomyces cerevisiae
0.063
-
ADPribose
-
Haemophilus influenzae
0.067
-
ADPribose
-
Escherichia coli
0.114
-
ADPribose
-
Bacillus subtilis
0.34
-
ADPribose
-
Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADPribose + H2O Escherichia coli the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O Saccharomyces cerevisiae the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O Cereibacter sphaeroides the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O Methanocaldococcus jannaschii the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O Bacillus subtilis the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O Haemophilus influenzae the enzyme may play a role in tellurite resistance AMP + D-ribose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P54570
-
-
Cereibacter sphaeroides
-
-
-
Escherichia coli
-
-
-
Haemophilus influenzae P44684
-
-
Methanocaldococcus jannaschii
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADPribose + H2O
-
Escherichia coli AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O
-
Saccharomyces cerevisiae AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O
-
Cereibacter sphaeroides AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O
-
Methanocaldococcus jannaschii AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O
-
Bacillus subtilis AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O
-
Haemophilus influenzae AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Escherichia coli AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Saccharomyces cerevisiae AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Cereibacter sphaeroides AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Methanocaldococcus jannaschii AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Bacillus subtilis AMP + D-ribose 5-phosphate
-
?
ADPribose + H2O the enzyme may play a role in tellurite resistance Haemophilus influenzae AMP + D-ribose 5-phosphate
-
?
GDP-mannose + H2O
-
Escherichia coli GMP + D-mannose 1-phosphate
-
?
GDP-mannose + H2O at 59% of the activity with ADPribose Haemophilus influenzae GMP + D-mannose 1-phosphate
-
?
GDP-mannose + H2O at 9% of the activity with ADPribose Saccharomyces cerevisiae GMP + D-mannose 1-phosphate
-
?
GDP-mannose + H2O at 1% of the activity with ADPribose Saccharomyces cerevisiae GMP + D-mannose 1-phosphate
-
?
NADH + H2O at 9% of the activity with ADPribose Escherichia coli ?
-
?
NADH + H2O at 12% of the activity with ADPribose Saccharomyces cerevisiae ?
-
?
NADH + H2O at 2% of the activity with ADPribose Bacillus subtilis ?
-
?
NADH + H2O at 15% of the activity with ADPribose Haemophilus influenzae ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.9
-
ADPribose
-
Methanocaldococcus jannaschii
7.92
-
ADPribose
-
Saccharomyces cerevisiae
9.2
-
ADPribose
-
Haemophilus influenzae
64.8
-
ADPribose
-
Bacillus subtilis
117
-
ADPribose
-
Escherichia coli