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Literature summary for 3.6.1.13 extracted from

  • Kim, J.S.; Kim, W.Y.; Rho, H.W.; Park, J.W.; Park, B.H.; Han, M.K.; Kim, U.H.; Kim, H.R.
    Purification and characterization of adenosine diphosphate ribose pyrophosphatase from human erythrocytes (1998), Int. J. Biochem. Cell Biol., 30, 629-638.
    View publication on PubMed
Search for more literature for 3.6.1.13

Inhibitors

Inhibitors Comment Organism Structure
ADP potent noncompetitive inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.169
-
 ADPribose
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 2 * 34000, SDS-PAGE with and without mercaptoethanol Homo sapiens
68000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADPribose + H2O Homo sapiens the enzyme may play an important role in the regulation of intracellular steady-state of free ADPribose AMP + D-ribose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.59
-
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, no loss of activity after months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-glucose + H2O at 21% of the activity with ADPribose Homo sapiens AMP + alpha-D-glucose 1-phosphate
-
 ?
ADP-mannose + H2O at 70% of the activity with ADPribose Homo sapiens AMP + D-mannose 1-phosphate
-
 ?
ADPribose + H2O
-
 Homo sapiens AMP + D-ribose 5-phosphate
-
 ?
ADPribose + H2O the enzyme may play an important role in the regulation of intracellular steady-state of free ADPribose Homo sapiens AMP + D-ribose 5-phosphate
-
 ?
CDP-glucose + H2O at 5% of the activity with ADPribose Homo sapiens CMP + glucose 5-phosphate
-
 ?
GDP-mannose + H2O at 40% of the activity with ADPribose Homo sapiens GMP + D-mannose 1-phosphate
-
 ?
IDP-ribose + H2O at 59% of the activity with ADPribose Homo sapiens IMP + ribose 5-phosphate
-
 ?
UDP-glucose + H2O at 5% of the activity with ADPribose Homo sapiens UMP + glucose 5-phosphate
-
 ?
UDP-mannose + H2O at 20% of the activity with ADPribose Homo sapiens UMP + D-mannose 1-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 34000, SDS-PAGE with and without mercaptoethanol Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
 Homo sapiens