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Literature summary for 3.5.4.9 extracted from

  • Vickers, T.; Murta, S.; Mandell, M.; Beverley, S.
    The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major (2009), Mol. Biochem. Parasitol., 166, 142-152.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.9

Inhibitors

Inhibitors Comment Organism Structure
N5,N10-carbonyl tetrahydrofolate
-
 Leishmania donovani
N5,N10-carbonyl tetrahydrofolate
-
 Leishmania infantum
N5,N10-carbonyl tetrahydrofolate
-
 Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Leishmania major 5829
-
mitochondrion
-
 Leishmania infantum 5739
-
additional information DHCH1 is not localized in the mitochondrion or other vesicular compartments Leishmania major
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O Leishmania major
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Leishmania infantum
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Leishmania donovani
-
 10-formyltetrahydrofolate
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani B8Y658
-
-
Leishmania donovani B8Y659
-
-
Leishmania infantum
-
-
-
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O
-
 Leishmania major 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Leishmania infantum 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Leishmania donovani 10-formyltetrahydrofolate
-
 ?

Synonyms

Synonyms Comment Organism
DHCH 1 isozyme Leishmania major
DHCH 1 isozyme Leishmania donovani
DHCH 2 isozyme Leishmania infantum
DHCH 2 isozyme Leishmania donovani
methylene-tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional enzyme Leishmania major
methylene-tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional enzyme Leishmania infantum
methylene-tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional enzyme Leishmania donovani

Cofactor

Cofactor Comment Organism Structure
additional information no increase in activity over wild type is seen in extracts from the DHCH2-overexpressors, using either NADP+ or NAD+ as the coenzyme Leishmania infantum
NADP+ NADP+-dependent enzyme Leishmania major