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Literature summary for 3.5.4.9 extracted from

  • Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
    Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos (2010), J. Biol. Chem., 285, 4612-4620.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.9

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O Mus musculus
-
 10-formyltetrahydrofolate
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O
-
 Mus musculus 10-formyltetrahydrofolate
-
 r

Synonyms

Synonyms Comment Organism
5,10-methenyl-THF cyclohydrolase
-
 Mus musculus
methenyl-tetrahydrofolate cyclohydrolase
-
 Mus musculus
methenyl-THF cyclohydrolase
-
 Mus musculus
MTHFD2 bifunctional enzyme possessing methenyl-tetrahydrofolate cyclohydrolase and dehydrogenase activities Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Mus musculus

Expression

Organism Comment Expression
Mus musculus MTHFD2 expression is high during early development but decreases as birth approaches down