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Literature summary for 3.5.4.9 extracted from

  • Pelletier, J.N.; MacKenzie, R.E.
    Binding to the 2',5'-ADP subsite stimulates cyclohydrolase activity of human NADP+-dependent methylenetetrahydrofolate dehydrogenase/cyclohydrolase (1994), Biochemistry, 33, 1900-1906.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2',5'-ADP micromolar concentrations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',5'-ADP millimolar concentrations Homo sapiens
NADP+
-
Homo sapiens
NADP+
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0164
-
(6R,S)-methenyltetrahydrofolate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O Homo sapiens
-
10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O Saccharomyces cerevisiae
-
10-formyltetrahydrofolate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
bifunctional domain of trifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase
-
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Storage Stability

Storage Stability Organism
-80°C, 50 mM potassium phosphate, 30% glycerol buffer, stable for over 1 month Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R,S)-methenyltetrahydrofolate + H2O
-
Homo sapiens ?
-
?
5,10-methenyltetrahydrofolate + H2O
-
Homo sapiens 10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O
-
Sus scrofa 10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O
-
Saccharomyces cerevisiae 10-formyltetrahydrofolate
-
?