Literature summary for 3.5.4.9 extracted from

Cohen, L.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme (1978), Biochim. Biophys. Acta, 522, 311-317.

Search for more literature for 3.5.4.9

Inhibitors

Inhibitors	Comment	Organism	Structure
folate	competitive inhibition	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
10-formyltetrahydrofolate	Sus scrofa	-	5,10-methenyltetrahydrofolate + H2O	-	r
5,10-methenyltetrahydrofolate + H2O	Sus scrofa	-	10-formyltetrahydrofolate	-	r
5,10-methenyltetrahydrofolate + H2O	Saccharomyces cerevisiae	-	10-formyltetrahydrofolate	-	?
5,10-methenyltetrahydrofolate + H2O	Ovis aries	-	10-formyltetrahydrofolate	-	?

Organism

Organism	UniProt	Comment	Textmining
Ovis aries	-	sheep, trifunctional enzyme	-
Saccharomyces cerevisiae	-	yeast, trifunctional enzyme	-
Sus scrofa	-	pig, trifunctional enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
10-formyltetrahydrofolate	-	Sus scrofa	5,10-methenyltetrahydrofolate + H2O	-	r
5,10-methenyltetrahydrofolate + H2O	-	Sus scrofa	10-formyltetrahydrofolate	-	r
5,10-methenyltetrahydrofolate + H2O	-	Saccharomyces cerevisiae	10-formyltetrahydrofolate	-	?
5,10-methenyltetrahydrofolate + H2O	-	Ovis aries	10-formyltetrahydrofolate	-	?

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Release 2023.1 (January 2023)