Organism | UniProt | Comment | Textmining |
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Source Tissue | Comment | Organism | Textmining |
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General Information | Comment | Organism |
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malfunction | patients with hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase, which is required for class switch recombination and somatic hypermutation, are prone to develop autoimmune diseases. Defective peripheral B-cell tolerance checkpoint occurs in AID-deficient patients, overview | Homo sapiens |
physiological function | AID is required for the establishment of both central and peripheral B-cell tolerance | Homo sapiens |