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Literature summary for 3.5.4.5 extracted from

  • Vincenzetti, S.; Mariani, P.L.; Cammertoni, N.; Polzonetti, V.; Natalini, P.; Quadrini, B.; Volpini, R.; Vita, A.
    Isoenzymatic forms of human cytidine deaminase (2004), Protein Eng. Des. Sel., 17, 871-877.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(cytidyl)acryloylaminohexanoic acid i.e. CV6 Homo sapiens
3,4,5,6-Tetrahydrouridine
-
Homo sapiens
5,6-Dihydrouridine
-
Homo sapiens
5-fluorozebularine
-
Homo sapiens
cytidine monophosphate
-
Homo sapiens
uridine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
2'-deoxycytidine native enzyme, 37°C Homo sapiens
0.04
-
cytidine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.04
-
2'-deoxycytidine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.042
-
2'-deoxycytidine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.042
-
cytidine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.087
-
5-iododeoxycytidine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.1
-
5-iododeoxycytidine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.11
-
cytosine arabinoside tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.15
-
cytosine arabinoside tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.28
-
5-azacytidine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.31
-
5-azacytidine tetramer of recombinant subunit CDA1, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15000
-
4 * 15000, SDS-PAGE Homo sapiens
60000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta different arrangement of subunit isoforms CDA1 and CDA2 results in five isoforms differing only in isoelectric point, native and recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxycytidine + H2O
-
Homo sapiens 2'-deoxyuridine + NH3
-
?
5-azacytidine + H2O
-
Homo sapiens 5-azauridine + NH3
-
?
5-iododeoxycytidine + H2O
-
Homo sapiens 5-iododeoxyuridine + NH3
-
?
cytidine + H2O
-
Homo sapiens uridine + NH3
-
?
cytosine arabinoside + H2O
-
Homo sapiens uridine arabinoside + NH3
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 15000, SDS-PAGE Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00006
-
5-fluorozebularine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.0003
-
5-fluorozebularine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.007
-
3,4,5,6-Tetrahydrouridine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.007
-
3,4,5,6-Tetrahydrouridine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.015
-
5,6-Dihydrouridine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.034
-
(cytidyl)acryloylaminohexanoic acid tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.04
-
5,6-Dihydrouridine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.045
-
(cytidyl)acryloylaminohexanoic acid tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.3
-
cytidine monophosphate tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.31
-
uridine tetramer of recombinant subunit CDA1, 37°C Homo sapiens
0.31
-
uridine tetramer of recombinant subunit CDA2, 37°C Homo sapiens
0.39
-
cytidine monophosphate tetramer of recombinant subunit CDA1, 37°C Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens tetramer of recombinant subunit CDA2, isoelectric focusing
-
4.5
Homo sapiens 5 different isoforms of native enzyme, isoelectric focusing 4.9 4.55
Homo sapiens tetramer of recombinant subunit CDA1, isoelectric focusing
-
5