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Literature summary for 3.5.4.5 extracted from
- On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase (1975), Biochemistry, 14, 5099-5105.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| uridine | product inhibition | Escherichia coli |  |
| uridine | inhibition relatively slow | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0092 | - |
cytidine | - |
Homo sapiens | |
| 0.058 | - |
5-azacytidine | - |
Homo sapiens | |
| 4.2 | - |
6-azacytidine | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytidine + H2O | Escherichia coli | - |
uridine + NH3 | - |
? | |
| cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
human | - |
| Homo sapiens | - |
HeLa cells | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| granulocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrocytidine + H2O | - |
Escherichia coli | 5,6-dihydrouridine + NH3 | - |
? | |
| 5-azacytidine + H2O | - |
Escherichia coli | 5-azauridine + NH3 | - |
? | |
| 5-azacytidine + H2O | - |
Homo sapiens | 5-azauridine + NH3 | - |
? | |
| 6-azacytidine + H2O | - |
Homo sapiens | 6-azauridine + NH3 | - |
? | |
| cytidine + H2O | - |
Escherichia coli | uridine + NH3 | - |
? | |
| cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
| cytosine arabinoside + H2O | - |
Escherichia coli | uridine arabinoside + NH3 | - |
? | |
| cytosine arabinoside + H2O | - |
Homo sapiens | uridine arabinoside + NH3 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
- |
Homo sapiens |
| 8 | - |
- |
Homo sapiens |
| 10 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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