Application | Comment | Organism |
---|---|---|
medicine | ADA2 is a drug candidate to modulate the immune responses during inflammation and cancer. ADA2 and its inhibitors are drug candidates to activate the immune systems of immunocompromised patients and to treat various types of blood cancers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
isozyme ADA2 is expressed in S2 Drosophila cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-erythro-9-(2-hydroxy-3-nonyl)adenine | specific inhibitor of ADA1 | Homo sapiens | |
coformycin | complete inhibition of ADA2 at 1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00813 | - |
- |
Homo sapiens | Q9NZK5 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant isozyme ADA2 is purified by heparin affinity column chromatography, Ni-chelate column chromatography, and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
monocyte | ADA2 is secreted by promonocytic cell lines and blood monocytes differentiated into macrophages and dendritic cells | Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine + H2O | - |
Homo sapiens | inosine + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADA1 | isozyme | Homo sapiens |
ADA2 | isozyme | Homo sapiens |
adenosine deaminase 1 | isozyme | Homo sapiens |
adenosine deaminase 2 | isozyme | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interferon gamma inhibits secretion of ADA2 by macrophages | down |
General Information | Comment | Organism |
---|---|---|
physiological function | isozyme ADA1 does not induce T cell-dependent differentiation of monocytes into macrophages | Homo sapiens |
physiological function | isozyme ADA2 but not ADA1 induces T cell-dependent differentiation of monocytes into macrophages and stimulates macrophage proliferation. ADA2 exhibits a growth factor activity and increases proliferation of CD4+ T cells. ADA2 binds to cells via proteoglycans and adenosine receptors | Homo sapiens |