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Literature summary for 3.5.4.4 extracted from

  • Zavialov, A.V.; Gracia, E.; Glaichenhaus, N.; Franco, R.; Zavialov, A.V.; Lauvau, G.
    Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages (2010), J. Leukoc. Biol., 88, 279-290.
    View publication on PubMed
Search for more literature for 3.5.4.4

Application

Application Comment Organism
medicine ADA2 is a drug candidate to modulate the immune responses during inflammation and cancer. ADA2 and its inhibitors are drug candidates to activate the immune systems of immunocompromised patients and to treat various types of blood cancers Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
isozyme ADA2 is expressed in S2 Drosophila cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(+)-erythro-9-(2-hydroxy-3-nonyl)adenine specific inhibitor of ADA1 Homo sapiens
coformycin complete inhibition of ADA2 at 1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00813
-
-
Homo sapiens Q9NZK5
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant isozyme ADA2 is purified by heparin affinity column chromatography, Ni-chelate column chromatography, and gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
monocyte ADA2 is secreted by promonocytic cell lines and blood monocytes differentiated into macrophages and dendritic cells Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
 Homo sapiens inosine + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADA1 isozyme Homo sapiens
ADA2 isozyme Homo sapiens
adenosine deaminase 1 isozyme Homo sapiens
adenosine deaminase 2 isozyme Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interferon gamma inhibits secretion of ADA2 by macrophages down

General Information

General Information Comment Organism
physiological function isozyme ADA1 does not induce T cell-dependent differentiation of monocytes into macrophages Homo sapiens
physiological function isozyme ADA2 but not ADA1 induces T cell-dependent differentiation of monocytes into macrophages and stimulates macrophage proliferation. ADA2 exhibits a growth factor activity and increases proliferation of CD4+ T cells. ADA2 binds to cells via proteoglycans and adenosine receptors Homo sapiens