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Literature summary for 3.5.4.4 extracted from

  • Kowalczyk, E.; Kopff, M.; Kowalski, J.; Kopff, A.; Mikhailidis, D.P.; Barylski, M.; Banach, M.
    Effect of cardiovascular drugs on adenosine deaminase activity (2008), Angiology, 59, 740-744.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aspirin significantly decreases adenosine deaminase activity, the half-life of adenosine will be lengthened as a consequence of decreased adenosine deaminase activity Oryctolagus cuniculus
erythro-9-(2-hydroxy-3-nonyl)-adenine 0.1 mM concentration, ADA2 is practically unaffected; 0.1 mM concentration, complete and reversible inhibition Oryctolagus cuniculus
isosorbide mononitrate significantly decreases adenosine deaminase activity, the half-life of adenosine will be lengthened as a consequence of decreased adenosine deaminase activity Oryctolagus cuniculus
metoprolol significantly decreases adenosine deaminase activity, the half-life of adenosine will be lengthened as a consequence of decreased adenosine deaminase activity Oryctolagus cuniculus
additional information ADA1 activity is not changed significantly by aspirin, metoprolol, isosorbide mononitrate, and molsidominemolsidomine; molsidomine does not influence plasma adenosine deaminase activity significantly Oryctolagus cuniculus
simvastatin inhibits ADA1 activity by 46.7%; significantly decreases adenosine deaminase activity, the half-life of adenosine will be lengthened as a consequence of decreased ADA activity Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Oryctolagus cuniculus 5737
-
extracellular
-
Oryctolagus cuniculus
-
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Oryctolagus cuniculus
-
erythrocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
Oryctolagus cuniculus inosine + NH3
-
?

Synonyms

Synonyms Comment Organism
ADA1
-
Oryctolagus cuniculus
ADA2
-
Oryctolagus cuniculus
adenosine deaminase
-
Oryctolagus cuniculus