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Literature summary for 3.5.4.4 extracted from

  • Van De Wiele, C.J.; Joachims, M.L.; Fesler, A.M.; Vaughn, J.G.; Blackburn, M.R.; McGee, S.T.; Thompson, L.F.
    Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture (2006), J. Immunol., 176, 5925-5933.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.4

Protein Variants

Protein Variants Comment Organism
additional information ADA-deficiency in mice inhibits the further differentiation of double positive CD4+CD8+ thymocytes in fetal thymic organ culture, the later stages of thymocyte development are sensitive to a lack of ADA, the block is mediated by a mitochondria-dependent mechanism. ADA-deficient cultures are partially rescued by the pan-caspase inhibitor carbobenzoxy-Val-Ala-Asp-fluoromethyl ketone or by the use of Apaf-1-deficient mice lacking apoptotic protease-activating factor-1, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxycoformycin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + H2O Mus musculus the enzyme is important in thymocyte development, especially in late stages, overview inosine + NH3
-
 ?
adenosine + H2O Mus musculus C57BL/6 the enzyme is important in thymocyte development, especially in late stages, overview inosine + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
 Mus musculus inosine + NH3
-
 ?
adenosine + H2O the enzyme is important in thymocyte development, especially in late stages, overview Mus musculus inosine + NH3
-
 ?
adenosine + H2O
-
 Mus musculus C57BL/6 inosine + NH3
-
 ?
adenosine + H2O the enzyme is important in thymocyte development, especially in late stages, overview Mus musculus C57BL/6 inosine + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADA
-
 Mus musculus