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Literature summary for 3.5.4.4 extracted from
- Conversion of viramidine to ribavirin in vivo by adenosine deaminase and its inhibition by 2-deoxycoformycin (2006), Antiviral Chem. Chemother., 17, 33-39.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Deoxycoformycin | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| viramidine + H2O | Rattus norvegicus | the enzyme catalyzes viramidine deamination to ribavirin in vivo as a prodrug conversion to active drug, pharmacokinetic analysis, overview | ribavirin + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| viramidine + H2O | the enzyme catalyzes viramidine deamination to ribavirin in vivo as a prodrug conversion to active drug, pharmacokinetic analysis, overview | Rattus norvegicus | ribavirin + NH3 | - |
? | |
| viramidine + H2O | substrate and product determination by LC-MS | Rattus norvegicus | ribavirin + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADA | - |
Rattus norvegicus |
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