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Literature summary for 3.5.4.4 extracted from

  • Iwaki-Egawa, S.; Namiki, C.; Watanabe, Y.
    Adenosine deaminase 2 from chicken liver: purification, characterization, and N-terminal amino acid sequence (2004), Comp. Biochem. Physiol. B, 137, 247-254.
    View publication on PubMed
Search for more literature for 3.5.4.4

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxycoformycin 0.15 nM, 50% inhibition Gallus gallus
additional information no inhibition by erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.144
-
 adenosine
-
 Gallus gallus
0.333
-
 2'-deoxyadenosine
-
 Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
 2 * 61000, SDS-PAGE Gallus gallus
110000
-
 gel filtration Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein following treatment with N-glycosidase, the molecular weight changes from 61000 Da to 55000 Da Gallus gallus

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosine + H2O 118.9% of the activity with adenosine Gallus gallus 2'-deoxyinosine + NH3
-
 ?
5'-AMP + H2O 1.4% of the activity with adenosine Gallus gallus 5'-IMP + NH3
-
 ?
adenosine + H2O
-
 Gallus gallus inosine + NH3
-
 ?
additional information the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system Gallus gallus ?
-
 ?
additional information no activity with 3'-deoxyadenosine, 2',3'-deoxyadenosine and 2'-O-methyladenosine Gallus gallus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 61000, SDS-PAGE Gallus gallus

Synonyms

Synonyms Comment Organism
ADA2
-
 Gallus gallus
adenosine deaminase 2
-
 Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Gallus gallus