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Literature summary for 3.5.4.4 extracted from

  • Lupidi, G.; Marmocchi, F.; Cristalli, G.
    Inhibition studies on membrane adenosine deaminase from human placenta (1998), Biochem. Mol. Biol. Int., 46, 1071-1080.
    View publication on PubMed
Search for more literature for 3.5.4.4

Application

Application Comment Organism
medicine therapy for adenosine-deficient patients with combined immunodeficiency Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
aza adenosine analogues
-
 Homo sapiens
deaza adenosine analogues
-
 Homo sapiens
Deoxycoformycin
-
 Homo sapiens
erythro-9-(2-hydroxy-3-nonyl)adenine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033
-
 adenosine
-
 Homo sapiens
0.052
-
 2'-deoxyadenosine
-
 Homo sapiens
0.081
-
 6-methoxypurinriboside
-
 Homo sapiens
0.277
-
 6-chloropurinriboside
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 normal B-cells and T-cell lines MOLT-4
-
Homo sapiens
-
 RPMI-8402
-
Homo sapiens
-
 CCRF-CEM
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosine + H2O
-
 Homo sapiens 2'-deoxyinosine + NH3
-
 ?
6-chloropurine riboside + H2O
-
 Homo sapiens inosine + Cl-
-
 ?
6-chloropurinriboside + H2O
-
 Homo sapiens inosine + Cl-
-
 ?
6-methoxypurinriboside
-
 Homo sapiens ?
-
 ?
adenosine + H2O
-
 Homo sapiens inosine + NH3
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Homo sapiens