Any feedback?
Literature summary for 3.5.4.3 extracted from
- Enzymatic evidence for a mitochondrial inhibitor of guanine aminohydrolase in rat liver (1982), Korean J. Biochem., 14, 77-93.
No PubMed abstract available
General Stability
| General Stability | Organism |
|---|---|
| stable to heat | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-aminoimidazole-4-carboxamide | - |
Homo sapiens |  |
| 5-aminoimidazole-4-carboxamide | - |
Rattus norvegicus | |
| Ag+ | 6.5% inhibition at 2 mM | Rattus norvegicus | |
| Fe3+ | - |
Rattus norvegicus | |
| Hg2+ | 98.6% inhibition at 2 mM | Rattus norvegicus | |
| Li+ | - |
Rattus norvegicus | |
| natural inhibitor protein | - |
Homo sapiens | |
| natural inhibitor protein | - |
Mus musculus | |
| natural inhibitor protein | heat labile proteinous mitochondrial inhibitor for liver and brain enzyme | Rattus norvegicus | |
| Pb2+ | 55.5% inhibition at 2 mM | Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | Mus musculus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Ophiodon elongatus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Clostridium sp. | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Rattus norvegicus Sprague Dawley | - |
xanthine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium sp. | - |
C. acidiurici | - |
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Ophiodon elongatus | - |
lingcod | - |
| Rattus norvegicus | - |
Sprague Dawley strain | - |
| Rattus norvegicus Sprague Dawley | - |
Sprague Dawley strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| muscle | - |
Homo sapiens | - |
| muscle | - |
Ophiodon elongatus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.14 | - |
purified liver enzyme | Rattus norvegicus |
| 1.36 | - |
kidney enzyme | Rattus norvegicus |
| 9.9 | - |
liver enzyme, isoenzyme A | Rattus norvegicus |
| 13.2 | - |
brain enzyme | Rattus norvegicus |
| 23.5 | - |
lung enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | - |
Mus musculus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Ophiodon elongatus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Clostridium sp. | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Rattus norvegicus Sprague Dawley | xanthine + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| dimer | - |
Rattus norvegicus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
- |
80 | - |
Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
activity remains unaffected from 0-50°C, 19.3% inactivation at 60°C, 33% inactivation at 70°C, complete lost of activity at 80°C | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
