Literature summary for 3.5.4.19 extracted from

Gupta, M.; Prasad, Y.; Sharma, S.K.; Jain, C.K.
Identification of phosphoribosyl-AMP cyclohydrolase, as drug target and its inhibitors in Brucella melitensis bv. 1 16M using metabolic pathway analysis (2017), J. Biomol. Struct. Dyn., 35, 287-299 .

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Application

Application	Comment	Organism
drug development	the enzyme is identified as drug target. Brucella melitensis is a pathogenic gram-negative bacterium which is known for causing zoonotic diseases (Brucellosis). The organism is highly contagious and is used as bioterrorism agent against humans	Brucella melitensis bv. 1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	ZINC04880153 can be considered as one of the potential lead molecule against HisI drug target in Brucella melitensis. Low binding energy (-9.1kcal/mol) with a molecular weight of 228.191 g/mol. It has 2 H-bond donors and 7 H-bond acceptors. The movement of ZINC04880153 in the binding pockets of HisI shows stability and compact structure with respect to the initial computational model of HisI	Brucella melitensis bv. 1

Organism

Organism	UniProt	Comment	Textmining
Brucella melitensis bv. 1	Q8YH95	-	-
Brucella melitensis bv. 1 ATCC 23456	Q8YH95	-	-

Synonyms

Synonyms	Comment	Organism
HisI	-	Brucella melitensis bv. 1

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in many important pathways such as biosynthesis of amino acids	Brucella melitensis bv. 1

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Release 2023.1 (January 2023)