Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O | Homo sapiens | catalyzation of the final two steps of de novo purine biosynthesis pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31939 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phophorylation increases enzyme activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anaplastic large cell lymphoma cell | ALCL cell line TS, Sup-M2 cells, JB-6 cells, SU-DHL1 cells | Homo sapiens | - |
CCRF-CEM cell | - |
Homo sapiens | - |
HEK-293T cell | immunoprecipitated from | Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
KARPAS-299 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
proteomic approach to identify phophorylated proteins with a pathogenic role in transformation mediated by anaplastic lymphoma kinase (ALK), profiling of tyrosine-phosphorylation, mass spectrometry, anti-phosphotyrosine protein immunoprecipitation, posttranslational modification of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) formyltransferase/inosine monophosphate (IMP) cyclohydrolase (AICAR-FT/IMP-CHase, ATIC) by phosphorylation, enzyme is a direct target of anaplastic lymphoma kinase (ALK), phoshorylation increases enzyme activity posttranslational modification of a key purine synthesis enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O | catalyzation of the final two steps of de novo purine biosynthesis pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AICAR-FT/IMP-CHase | - |
Homo sapiens |
ATIC | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |