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Literature summary for 3.5.4.1 extracted from

  • Dang, Y.; Abudu, A.; Son, S.; Harjes, E.; Spearman, P.; Matsuo, H.; Zheng, Y.H.
    Identification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity (2011), J. Virol., 85, 5691-5695.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
C320A mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320D mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320F mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320K mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320L mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320Q mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320S mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320T mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320W mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
C320Y A3DE catalytic activity is significantly increased which in turn increases antiviral activity by more than 20fold Homo sapiens
C320Y/E264Q insertion of E264Q mutation completely disrupts C320Y activity, virion packaging capability is not impaired. Thus, the activity of C320Y does require an active cytidine deaminase Homo sapiens
DELTA307 mutant shows disrupted anti-HIV activity Homo sapiens
DELTA320 deletion mutant shows anti-HIV-1 activity comparable to wild-type Homo sapiens
Y307A mutant shows disrupted anti-HIV activity Homo sapiens
Y307C mutant shows disrupted anti-HIV activity Homo sapiens
Y307K mutant shows disrupted anti-HIV activity Homo sapiens
Y307R mutant shows disrupted anti-HIV activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
A3DE
-
 Homo sapiens
APOBEC3
-
 Homo sapiens