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Literature summary for 3.5.4.1 extracted from

  • Li, M.; Shandilya, S.M.; Carpenter, M.A.; Rathore, A.; Brown, W.L.; Perkins, A.L.; Harki, D.A.; Solberg, J.; Hook, D.J.; Pandey, K.K.; Parniak, M.A.; Johnson, J.R.; Krogan, N.J.; Somasundaran, M.; Ali, A.; Schiffer, C.A.; Harris, R.S.
    First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G (2012), ACS Chem. Biol., 7, 506-517.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.1

Inhibitors

Inhibitors Comment Organism Structure
(1R,2S)-(-)-ephedrine
-
 Homo sapiens
(alpha-D-glucopyranosylthio)gold
-
 Homo sapiens
(R)-2,10,11-trihydroxy-N-propyl-noraporphine
-
 Homo sapiens
(R)-2,10,11-trihydroxyaporphine
-
 Homo sapiens
(R)-apomorphine
-
 Homo sapiens
(R)-N-allylnorapomorphine
-
 Homo sapiens
(R)-propylnorapomorphine
-
 Homo sapiens
(S)-carbidopa
-
 Homo sapiens
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
-
 Homo sapiens
3,4-dihydroxyphenylacetic acid
-
 Homo sapiens
4-chloromercuribenzoic acid
-
 Homo sapiens
4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
-
 Homo sapiens
5'-guanidinonaltrindole
-
 Homo sapiens
6-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
-
 Homo sapiens
6-hydroxy-DL-DOPA
-
 Homo sapiens
aurintricarboxylic acid
-
 Homo sapiens
caffeic acid
-
 Homo sapiens
cephapirin
-
 Homo sapiens
dephostatin
-
 Homo sapiens
dihydrexidine
-
 Homo sapiens
ebselen
-
 Homo sapiens
hispidin
-
 Homo sapiens
hydroquinone
-
 Homo sapiens
iodoacetamide
-
 Homo sapiens
methyl 3-hydroxy-DL-tyrosinate
-
 Homo sapiens
myricetin
-
 Homo sapiens
N-acetyldopamine
-
 Homo sapiens
nordihydroguaiaretic acid
-
 Homo sapiens
p-benzoquinone
-
 Homo sapiens
piceatannol
-
 Homo sapiens
PPNDS tetrasodium
-
 Homo sapiens
SCH202676
-
 Homo sapiens
SKF-89626
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
 Homo sapiens 5-fluorouracil + NH3
-
 ?

Synonyms

Synonyms Comment Organism
APOBEC3G
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00013
-
 pH 7.4, 37°C Homo sapiens 4-chloromercuribenzoic acid
0.00017
-
 pH 7.4, 37°C Homo sapiens p-benzoquinone
0.00036
-
 pH 7.4, 37°C Homo sapiens (alpha-D-glucopyranosylthio)gold
0.00043
-
 pH 7.4, 37°C Homo sapiens dephostatin
0.00045
-
 pH 7.4, 37°C Homo sapiens N-acetyldopamine
0.00049
-
 pH 7.4, 37°C Homo sapiens aurintricarboxylic acid
0.00059
-
 pH 7.4, 37°C Homo sapiens dihydrexidine
0.0007
-
 pH 7.4, 37°C Homo sapiens 6-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
0.0013
-
 pH 7.4, 37°C Homo sapiens (R)-apomorphine
0.0013
-
 pH 7.4, 37°C Homo sapiens SKF-89626
0.0013
-
 pH 7.4, 37°C Homo sapiens (1R,2S)-(-)-ephedrine
0.0017
-
 pH 7.4, 37°C Homo sapiens (R)-2,10,11-trihydroxyaporphine
0.0018
-
 pH 7.4, 37°C Homo sapiens piceatannol
0.002
-
 pH 7.4, 37°C Homo sapiens hispidin
0.0026
-
 pH 7.4, 37°C Homo sapiens hydroquinone
0.0028
-
 pH 7.4, 37°C Homo sapiens ebselen
0.0029
-
 pH 7.4, 37°C Homo sapiens (R)-N-allylnorapomorphine
0.003
-
 pH 7.4, 37°C Homo sapiens iodoacetamide
0.0034
-
 pH 7.4, 37°C Homo sapiens myricetin
0.0035
-
 pH 7.4, 37°C Homo sapiens 4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
0.004
-
 pH 7.4, 37°C Homo sapiens 6-hydroxy-DL-DOPA
0.0053
-
 pH 7.4, 37°C Homo sapiens (S)-carbidopa
0.0056
-
 pH 7.4, 37°C Homo sapiens PPNDS tetrasodium
0.006
-
 pH 7.4, 37°C Homo sapiens (R)-propylnorapomorphine
0.0064
-
 pH 7.4, 37°C Homo sapiens 5'-guanidinonaltrindole
0.0075
-
 pH 7.4, 37°C Homo sapiens cephapirin
0.0088
-
 pH 7.4, 37°C Homo sapiens nordihydroguaiaretic acid
0.0091
-
 pH 7.4, 37°C Homo sapiens dephostatin
0.013
-
 pH 7.4, 37°C Homo sapiens methyl 3-hydroxy-DL-tyrosinate
0.013
-
 pH 7.4, 37°C Homo sapiens (R)-2,10,11-trihydroxy-N-propyl-noraporphine
0.019
-
 pH 7.4, 37°C Homo sapiens 3,4-dihydroxyphenylacetic acid
0.027
-
 pH 7.4, 37°C Homo sapiens 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
0.029
-
 pH 7.4, 37°C Homo sapiens SCH202676
0.085
-
 pH 7.4, 37°C Homo sapiens caffeic acid