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Literature summary for 3.5.4.1 extracted from

  • Song, Y.; Kong, B.; Ma, D.; Qu, X.; Jiang, S.
    Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer (2006), Int. J. Gynecol. Cancer, 16, 156-164.
    View publication on PubMed
Search for more literature for 3.5.4.1

Application

Application Comment Organism
medicine the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy, overview Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information construction of and transfection with vectors encoding Escherichia coli cytosine deaminase and herpes simplex virus thymidine kinase leads to greater cell death in procaspase-3-expressing clones of 3AO cells, ovarian cancer cells than in control cells after treatment with ganciclovir or 5-fluorocytosine, as well as more rapid activation of caspase-3 and more rapid cleavage of poly (adenosine diphosphate-ribose) polymerase, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?
additional information Escherichia coli the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy with procaspase-3 co-expression improving the method, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
 Escherichia coli 5-fluorouracil + NH3
-
 ?
cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?
additional information the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy with procaspase-3 co-expression improving the method, overview Escherichia coli ?
-
 ?