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Literature summary for 3.5.4.1 extracted from

  • Lee, K.C.; Hamstra, D.A.; Bullarayasamudram, S.; Bhojani, M.S.; Moffat, B.A.; Dornfeld, K.J.; Ross, B.D.; Rehemtulla, A.
    Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit (2006), Gene Ther., 13, 127-137.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information fusion of the HSV-1 tegument protein vp22, as full-length protein and as truncated protein lacking the trafficking residues, to cytosine deaminase and stable expression in 9L tumors confers enhanced bystander effect and increased therapeutic benefit in cancer gene therapy, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the cytosine deaminase gene acts as a suicide gene by catalyzing the conversion of 5-fluorocytosine to cytotoxic 5-fluorouracil, fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit in cancer gene therapy of gliosarcoma cells and murine 9L tumors, overview ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the cytosine deaminase gene acts as a suicide gene by catalyzing the conversion of 5-fluorocytosine to cytotoxic 5-fluorouracil, fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit in cancer gene therapy of gliosarcoma cells and murine 9L tumors, overview Saccharomyces cerevisiae ?
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