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Literature summary for 3.5.4.1 extracted from

  • Kaliberov, S.A.; Chiz, S.; Kaliberova, L.N.; Krendelchtchikova, V.; Della Manna, D.; Zhou, T.; Buchsbaum, D.J.
    Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity (2006), Cancer Gene Ther., 13, 203-214.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of a chimeric fusion protein consisting of cytosine deaminase and uracil phosphoribosyltransferase in human pancreatic cancer and glioma cell lines Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information construction of a chimeric fusion protein consisting of cytosine deaminase and uracil phosphoribosyltransferase in human pancreatic cancer and glioma cell lines, the recombinant fusion enzyme mediates 5-fluorouracil cell killing and leads to growth inhibition of tumor tissue, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli combination of cytosine deaminase suicide gene expression with treatment with antibody against human death receptor DR5 increases cancer cell cytotoxicity, the death receptors are involved in TNF-related factor-induced apoptosis, overview ?
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O activation of the prodrug to the cytotoxic drug in cancer therapy through the recombinant fusion enzyme cytosine deaminase/uracil phosphoribosyltransferase in human cancer cell lines, overview Escherichia coli 5-fluorouracil + NH3
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 ?
additional information combination of cytosine deaminase suicide gene expression with treatment with antibody against human death receptor DR5 increases cancer cell cytotoxicity, the death receptors are involved in TNF-related factor-induced apoptosis, overview Escherichia coli ?
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 ?