Cloned (Comment) | Organism |
---|---|
expression of a chimeric fusion protein consisting of cytosine deaminase and uracil phosphoribosyltransferase in human pancreatic cancer and glioma cell lines | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric fusion protein consisting of cytosine deaminase and uracil phosphoribosyltransferase in human pancreatic cancer and glioma cell lines, the recombinant fusion enzyme mediates 5-fluorouracil cell killing and leads to growth inhibition of tumor tissue, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | combination of cytosine deaminase suicide gene expression with treatment with antibody against human death receptor DR5 increases cancer cell cytotoxicity, the death receptors are involved in TNF-related factor-induced apoptosis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | activation of the prodrug to the cytotoxic drug in cancer therapy through the recombinant fusion enzyme cytosine deaminase/uracil phosphoribosyltransferase in human cancer cell lines, overview | Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
additional information | combination of cytosine deaminase suicide gene expression with treatment with antibody against human death receptor DR5 increases cancer cell cytotoxicity, the death receptors are involved in TNF-related factor-induced apoptosis, overview | Escherichia coli | ? | - |
? |