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Literature summary for 3.5.4.1 extracted from

  • Hidaka, A.; Hamaji, Y.; Sasaki, T.; Taniguchi, S.; Fujimori, M.
    Exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/prodrug therapy (2007), Biosci. Biotechnol. Biochem., 71, 2921-2926.
    View publication on PubMed
Search for more literature for 3.5.4.1

Application

Application Comment Organism
pharmacology exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/prodrug therapy, overview Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
expression of recombinant cytosine deaminase in Bifidobacterium breve I-53-8w using a shuttle plasmid Escherichia coli-Bifidobacterium, overview Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information expression of recombinant cytosine deaminase activity in Bifidobacterium breve I-53-8w is eefective in tumor-targeting enzyme/prodrug therapy in rats, phenotype, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
 Escherichia coli 5-fluorouracil + NH3
-
 ?
cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
 assay at Escherichia coli