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Literature summary for 3.5.4.1 extracted from
- Cytosine deaminase gene as a positive selection marker (1996), J. Biol. Chem., 271, 3812-3816.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | new approach to chemotherapy of cancer, using substrate 5-fluorocytosine orally and enzyme capsules implanted locally, using conversion of product 5-fluorouracil, a potent antineoplastic substance, which is strongly toxic for mammalian cells as chemotherapeutic tool against tumors, enzyme/prodrug gene therapy, artificial gene composed for metastatic colorectal carcinoma | Escherichia coli |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| therapeutic CDase gene for human metastatic colorectal carcinoma | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
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