Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-alanine | 1 mM, relative activity 120% | Escherichia coli | |
D-threonine | 1 mM, relative activity 120% | Escherichia coli | |
DL-alpha-amino-n-butyric acid | 1 mM, relative activity 140% | Escherichia coli | |
DL-homoserine | 1 mM, relative activity 110% | Escherichia coli | |
DL-isoleucine | 1 mM, relative activity 130% | Escherichia coli | |
DL-methionine | 1mM, relative activity 140% | Escherichia coli | |
EDTA | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
EDTA | 1 mM, relative activity 101% | Escherichia coli | |
glycine | 1 mM, relative activity 130% | Escherichia coli | |
L-amino acids | - |
Escherichia coli | |
L-amino acids | - |
Serratia marcescens | |
L-amino acids | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-aspartic acid | - |
Serratia marcescens | |
L-aspartic acid | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-aspartic acid | 1 mM, relative activity 130% | Escherichia coli | |
L-Glutamic acid | - |
Serratia marcescens | |
L-Glutamic acid | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-Glutamic acid | 1 mM, relative activity 120% | Escherichia coli | |
L-glutamine | - |
Serratia marcescens | |
L-glutamine | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-glutamine | 1 mM, relative activity 130% | Escherichia coli | |
L-histidine | - |
Serratia marcescens | |
L-histidine | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-histidine | 1 mM, relative activity 120% | Escherichia coli | |
L-hydroxyproline | - |
Serratia marcescens | |
L-hydroxyproline | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
L-hydroxyproline | 1 mM, relative activity 120% | Escherichia coli | |
L-isoleucine | 1 mM, relative activity 130% | Escherichia coli | |
L-leucine | 1 mM, relative activity 120% | Escherichia coli | |
L-ornithine | 1 mM, relative activity 120% | Escherichia coli | |
L-phenylalanine | 1 mM, relative activity 140% | Escherichia coli | |
L-serine | 1 mM, relative activity 140% | Escherichia coli | |
L-threonine | 1 mM, relative activity 120% | Escherichia coli | |
L-valine | 1 mM, relative activity 120% | Escherichia coli |
Application | Comment | Organism |
---|---|---|
medicine | - |
Saccharomyces cerevisiae |
medicine | new approach to chemotherapy of cancer, using substrate 5-fluorocytosine orally and enzyme capsules implanted locally, using conversion of product 5-fluorouracil, a potent antineoplastic substance, which is strongly toxic for mammalian cells as chemotherapeutic tool against tumors, enzyme/prodrug gene therapy, artificial gene composed for metastatic colorectal carcinoma | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ag+ | - |
Escherichia coli | |
Cu2+ | - |
Escherichia coli | |
Cu2+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Cu2+ | - |
Serratia marcescens | |
Hg(CH3COO)2 | - |
Escherichia coli | |
Hg+ | - |
Escherichia coli | |
Hg2+ | - |
Escherichia coli | |
Hg2+ | - |
Serratia marcescens | |
Mersalyl acid | - |
Escherichia coli | |
p-chloromercuribenzoic acid | - |
Escherichia coli | |
p-chloromercuriphenylsulfonic acid | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CaCl2 | - |
Pseudomonas chlororaphis subsp. aureofaciens | |
CaCl2 | 1 mM, relative activity 111% | Escherichia coli | |
MnCl2 | 1 mM, relative activity 113% | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
2 * 35000 + 2 * 46000, heterodimer, SDS-PAGE | Escherichia coli |
46000 | - |
2 * 35000 + 2 * 46000, heterodimer, SDS-PAGE | Escherichia coli |
200000 | - |
gel filtration | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Saccharomyces cerevisiae | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Serratia marcescens | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Pseudomonas chlororaphis subsp. aureofaciens | - |
uracil + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
K-12 IFO 3301 | - |
Pseudomonas chlororaphis subsp. aureofaciens | - |
IFO 3521 | - |
Saccharomyces cerevisiae | - |
baker's yeast | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Serratia marcescens | - |
IFO 3054 | - |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Saccharomyces cerevisiae |
- |
Serratia marcescens |
- |
Pseudomonas chlororaphis subsp. aureofaciens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9.8 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5-fluorouracil + NH3 | - |
? | |
5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
5-fluorocytosine + H2O | - |
Saccharomyces cerevisiae | 5-fluorouracil + NH3 | - |
? | |
cytosine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Saccharomyces cerevisiae | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Serratia marcescens | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Pseudomonas chlororaphis subsp. aureofaciens | uracil + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
tetramer | 2 * 35000 + 2 * 46000, heterodimer, SDS-PAGE | Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
- |
Escherichia coli |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
- |
Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Escherichia coli |
9 | - |
- |
Escherichia coli |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
9 | 10 | most stable at | Escherichia coli |