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Literature summary for 3.5.2.6 extracted from

  • Papp-Wallace, K.M.; Mallo, S.; Bethel, C.R.; Taracila, M.A.; Hujer, A.M.; Fernandez, A.; Gatta, J.A.; Smith, K.M.; Xu, Y.; Page, M.G.; Desarbre, E.; Bou, G.; Bonomo, R.A.
    A kinetic analysis of the inhibition of FOX-4 beta-lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic beta-lactams and carbapenems (2014), J. Antimicrob. Chemother., 69, 682-690.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene blaFOX-4, recombinant expression in Escherichia coli strain BL21(DE3) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
avibactam
-
Escherichia coli
aztreonam
-
Escherichia coli
BAL29880
-
Escherichia coli
BAL30072
-
Escherichia coli
doripenem
-
Escherichia coli
ertapenem
-
Escherichia coli
Imipenem
-
Escherichia coli
meropenem
-
Escherichia coli
MK-7655
-
Escherichia coli
additional information kinetic inhibitory profiles of monocyclic beta-lactams and carbapenems against FOX-4, overview Escherichia coli
RPX7009
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ampicillin + H2O Escherichia coli
-
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
a clinical strain isolated from a patient with a urinary tract infection in Spain, gene blaFOX-4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
additional information enzyme FOX-4 possesses broad substrate specificity for beta-lactam hydrolysis, especially cephamycins Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
Cephalosporinase
-
Escherichia coli
cephamycinase
-
Escherichia coli
class C cephalosporinase
-
Escherichia coli
FOX-4
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetic analysis, overview Escherichia coli
0.00004
-
aztreonam pH 74, temperature not specified in the publication Escherichia coli
0.00027
-
meropenem pH 74, temperature not specified in the publication Escherichia coli
0.00028
-
ertapenem pH 74, temperature not specified in the publication Escherichia coli
0.0007
-
BAL30072 pH 74, temperature not specified in the publication Escherichia coli
0.0011
-
Imipenem pH 74, temperature not specified in the publication Escherichia coli
0.0023
-
doripenem pH 74, temperature not specified in the publication Escherichia coli
0.009
-
BAL29880 pH 74, temperature not specified in the publication Escherichia coli