Cloned (Comment) | Organism |
---|---|
gene blaFOX-4, recombinant expression in Escherichia coli strain BL21(DE3) | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
avibactam | - |
Escherichia coli | |
aztreonam | - |
Escherichia coli | |
BAL29880 | - |
Escherichia coli | |
BAL30072 | - |
Escherichia coli | |
doripenem | - |
Escherichia coli | |
ertapenem | - |
Escherichia coli | |
Imipenem | - |
Escherichia coli | |
meropenem | - |
Escherichia coli | |
MK-7655 | - |
Escherichia coli | |
additional information | kinetic inhibitory profiles of monocyclic beta-lactams and carbapenems against FOX-4, overview | Escherichia coli | |
RPX7009 | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ampicillin + H2O | Escherichia coli | - |
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
a clinical strain isolated from a patient with a urinary tract infection in Spain, gene blaFOX-4 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ampicillin + H2O | - |
Escherichia coli | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
additional information | enzyme FOX-4 possesses broad substrate specificity for beta-lactam hydrolysis, especially cephamycins | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cephalosporinase | - |
Escherichia coli |
cephamycinase | - |
Escherichia coli |
class C cephalosporinase | - |
Escherichia coli |
FOX-4 | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetic analysis, overview | Escherichia coli | |
0.00004 | - |
aztreonam | pH 74, temperature not specified in the publication | Escherichia coli | |
0.00027 | - |
meropenem | pH 74, temperature not specified in the publication | Escherichia coli | |
0.00028 | - |
ertapenem | pH 74, temperature not specified in the publication | Escherichia coli | |
0.0007 | - |
BAL30072 | pH 74, temperature not specified in the publication | Escherichia coli | |
0.0011 | - |
Imipenem | pH 74, temperature not specified in the publication | Escherichia coli | |
0.0023 | - |
doripenem | pH 74, temperature not specified in the publication | Escherichia coli | |
0.009 | - |
BAL29880 | pH 74, temperature not specified in the publication | Escherichia coli |