Literature summary for 3.5.2.6 extracted from

Zhao, W.H.; Hu, Z.Q.; Chen, G.; Matsushita, K.; Fukuchi, K.; Shimamura, T.
Characterization of imipenem-resistant Serratia marcescens producing IMP-type and TEM-type beta-lactamases encoded on a single plasmid (2007), Microbiol. Res., 162, 46-52.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli strain JM109	Serratia marcescens

Inhibitors

Inhibitors	Comment	Organism	Structure
aztreonam	-	Serratia marcescens

Organism

Organism	UniProt	Comment	Textmining
Serratia marcescens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ampicillin + H2O	-	Serratia marcescens	(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid	-	?
cefotaxime + H2O	-	Serratia marcescens	(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cefoxitin + H2O	-	Serratia marcescens	(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cephalexin + H2O	-	Serratia marcescens	(2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
imipenem + H2O	-	Serratia marcescens	(5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid	-	?

Synonyms

Synonyms	Comment	Organism
IMP-type beta-lactamase	-	Serratia marcescens
TEM-type beta-lactamase	-	Serratia marcescens

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Release 2023.1 (January 2023)