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Literature summary for 3.5.2.6 extracted from

  • Taylor, S.J.C.; Sutherland, A.G.; Lee, C.; Wisdom, R.; Thomas, S.; Roberts, S.M.; Evans, C.
    Chemoenzymatic synthesis of (-)carbovir utilizing a whole cell catalyzed resolution of a 2-azabicyclo[2.2.1]hept-5-en-3-one (1990), J. Chem. Soc. Chem. Commun., 1990, 1120-1121.
No PubMed abstract available
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Application

Application Comment Organism
synthesis production of (-)2-azabicyclo[2.2.1]hept-5-en-3-one, which can be converted into carbovir, carbovir is a potent and selective inhibitor of HIV-1 Ralstonia solanacearum

Organism

Organism UniProt Comment Textmining
Ralstonia solanacearum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-azabicyclo[2.2.1]hept-5-en-3-one + H2O
-
 Ralstonia solanacearum (-)-2-azabicyclo[2.2.1]hept-5-en-3-one + (+)-4-amino-cyclopent-2-enecarboxylic acid
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
 Ralstonia solanacearum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Ralstonia solanacearum