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Literature summary for 3.5.2.6 extracted from
- beta-Lactamase (Bacillus licheniformis) (1975), Methods Enzymol., 43, 652-664.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| I2 | - |
Bacillus licheniformis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00023 | - |
Methicillin | strain 6346/C | Bacillus licheniformis | |
| 0.00093 | - |
Methicillin | strain 749/C | Bacillus licheniformis | |
| 0.009 | - |
benzylpenicillin | strain 6346/C | Bacillus licheniformis | |
| 0.0166 | - |
6-aminopenicillanic acid | both strains | Bacillus licheniformis | |
| 0.049 | - |
benzylpenicillin | strain 749/C | Bacillus licheniformis | |
| 0.05 | - |
cephalosporin C | strain 749/C | Bacillus licheniformis | |
| 0.05 | - |
benzylcephalosporin C | both strains | Bacillus licheniformis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Bacillus licheniformis | - |
- |
| plasma membrane | - |
Bacillus licheniformis | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 28500 | - |
calcultaed from amino acid composition | Bacillus licheniformis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus licheniformis | - |
- |
- |
| Bacillus licheniformis 6346/C | - |
- |
- |
| Bacillus licheniformis 749/C | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bacillus licheniformis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 900 | - |
strain 6346/C, exoenzyme | Bacillus licheniformis |
| 5417 | - |
strain 749/C, exoenzyme | Bacillus licheniformis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-aminopenicillanic acid + H2O | - |
Bacillus licheniformis | (2R,4S)-2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 6-aminopenicillanic acid + H2O | - |
Bacillus licheniformis 749/C | (2R,4S)-2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 6-aminopenicillanic acid + H2O | - |
Bacillus licheniformis 6346/C | (2R,4S)-2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| benzyl cephalosporin C + H2O | - |
Bacillus licheniformis | (2R)-5-[(acetyloxy)methyl]-2-[(R)-{[(5R)-5-amino-6-(benzyloxy)-6-oxohexanoyl]amino}(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| benzyl cephalosporin C + H2O | - |
Bacillus licheniformis 749/C | (2R)-5-[(acetyloxy)methyl]-2-[(R)-{[(5R)-5-amino-6-(benzyloxy)-6-oxohexanoyl]amino}(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| benzyl cephalosporin C + H2O | - |
Bacillus licheniformis 6346/C | (2R)-5-[(acetyloxy)methyl]-2-[(R)-{[(5R)-5-amino-6-(benzyloxy)-6-oxohexanoyl]amino}(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| benzylpenicillin + H2O | - |
Bacillus licheniformis | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| benzylpenicillin + H2O | - |
Bacillus licheniformis 749/C | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| benzylpenicillin + H2O | - |
Bacillus licheniformis 6346/C | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| cephalosporin C + H2O | - |
Bacillus licheniformis | N6-[(R)-{(2R)-5-[(acetyloxy)methyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-2-yl}(carboxy)methyl]-6-oxo-D-lysine | - |
? | |
| cephalosporin C + H2O | - |
Bacillus licheniformis 749/C | N6-[(R)-{(2R)-5-[(acetyloxy)methyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-2-yl}(carboxy)methyl]-6-oxo-D-lysine | - |
? | |
| cephalosporin C + H2O | - |
Bacillus licheniformis 6346/C | N6-[(R)-{(2R)-5-[(acetyloxy)methyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-2-yl}(carboxy)methyl]-6-oxo-D-lysine | - |
? | |
| methicillin + H2O | - |
Bacillus licheniformis | (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| methicillin + H2O | - |
Bacillus licheniformis 749/C | (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| methicillin + H2O | - |
Bacillus licheniformis 6346/C | (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
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