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Literature summary for 3.5.1.88 extracted from
- Peptide deformylase inhibitors with retro-amide scaffold: synthesis and structure-activity relationships (2010), Bioorg. Med. Chem. Lett., 20, 4317-4319.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[(2-methoxyphenyl)carbamoyl]prolyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa |  |
| 3-methyl-N-(1,3-thiazol-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(2-methylpropanoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(morpholin-4-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(phenylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(piperidin-1-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(pyridin-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(pyridin-3-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(pyridin-4-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-(thiophen-2-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| 3-methyl-N-[methyl(phenyl)carbamoyl]-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| actinonin | a naturally occurring PDF inhibitor | Pseudomonas aeruginosa | |
| N-(2-methoxybenzoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-(cyclohexylcarbamoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-benzoyl-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyethyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N-hydroxy-N2-(3-methylbutyl)glycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(2-cyclopentylethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclobutylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopropylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]alanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]leucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]norleucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]phenylalanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
| N-[(2-methoxyphenyl)carbamoyl]valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | - |
Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-L-methionine-polypeptide + H2O | Pseudomonas aeruginosa | - |
formate + L-methionine-polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | Q9I7A8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-L-methionine-polypeptide + H2O | - |
Pseudomonas aeruginosa | formate + L-methionine-polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
- |
Pseudomonas aeruginosa |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000011 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-(2-methoxybenzoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000013 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclobutylmethyl)-N-hydroxyglycinamide | |
| 0.000013 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000015 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopropylmethyl)-N-hydroxyglycinamide | |
| 0.000017 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(phenylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000019 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(thiophen-2-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000021 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N-hydroxy-N2-(3-methylbutyl)glycinamide | |
| 0.000028 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(morpholin-4-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000029 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000031 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(2-cyclopentylethyl)-N-hydroxyglycinamide | |
| 0.000032 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]leucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000036 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]norleucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000041 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-benzoyl-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000042 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyethyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000042 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]alanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000043 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(1,3-thiazol-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000047 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(piperidin-1-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000049 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(pyridin-3-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.00005 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-[methyl(phenyl)carbamoyl]-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000052 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(2-methylpropanoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000054 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(pyridin-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000055 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-(cyclohexylcarbamoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000061 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-methoxyphenyl)carbamoyl]phenylalanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000065 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-methyl-N-(pyridin-4-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
| 0.000116 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 1-[(2-methoxyphenyl)carbamoyl]prolyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide | |
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