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Literature summary for 3.5.1.88 extracted from

  • Yoon, H.; Kim, H.L.; Lee, S.; Kim, H.; Kim, H.; Lee, J.Y.; Mikami, B.; Suh, S.W.
    Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent (2004), Proteins, 57, 639-642.
    View publication on PubMed

Application

Application Comment Organism
medicine target for antibacterial agents against Staphylococcus aureus Staphylococcus aureus

Cloned(Commentary)

Cloned (Comment) Organism
for expession in Escherichia coli C41(DE3) cells with a C-terminal eight-residue, LEHHHHHH, tag Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of Staphylococcus aureus peptide deformylase, SaPDF, in complex with its inhibitor actinonin at 1.9 A resolution Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Staphylococcus aureus
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
purified by two chromatographic steps involving affinity and gel filtration columns Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Staphylococcus aureus formate + methionyl peptide
-
?

Synonyms

Synonyms Comment Organism
PDF
-
Staphylococcus aureus
peptide deformylase
-
Staphylococcus aureus
SaPDF
-
Staphylococcus aureus