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Literature summary for 3.5.1.88 extracted from

  • Cai, J.; Han, C.; Hu, T.; Zhang, J.; Wu, D.; Wang, F.; Liu, Y.; Ding, J.; Chen, K.; Yue, J.; Shen, X.; Jiang, H.
    Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation (2006), Protein Sci., 15, 2071-2081.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine target for anti-Helicobacter pylori drugs Helicobacter pylori

Cloned(Commentary)

Cloned (Comment) Organism
for over-expression in Escherichia coli BL21(DE3) cells Helicobacter pylori

Crystallization (Commentary)

Crystallization (Comment) Organism
apo-HpPDF, HpPDF - N-trans-caffeoyltyramine complex, HpPDF - (E)-N-phenethyl-3-(3,4-diacetoxyphenyl)acrylamide complex Helicobacter pylori

Inhibitors

Inhibitors Comment Organism Structure
(E)-N-phenethyl-3-(3,4-diacetoxyphenyl)acrylamide IC50: 0.00125 mM Helicobacter pylori
N-trans-caffeoyltyramine IC50: 0.0108 mM Helicobacter pylori

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
Helicobacter pylori
Fe2+
-
Helicobacter pylori
Ni2+
-
Helicobacter pylori
Zn2+
-
Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Helicobacter pylori
-
formate + L-methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori Q672W7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Helicobacter pylori formate + L-methionyl peptide
-
?
N-formyl-L-Met-L-Ala-L-Ser + H2O activity assay Helicobacter pylori formate + L-Met-L-Ala-L-Ser
-
?

Synonyms

Synonyms Comment Organism
HpPDF
-
Helicobacter pylori
PDF
-
Helicobacter pylori
peptide deformylase
-
Helicobacter pylori

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
activity assay Helicobacter pylori

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00125
-
IC50: 0.00125 mM Helicobacter pylori (E)-N-phenethyl-3-(3,4-diacetoxyphenyl)acrylamide
0.0108
-
IC50: 0.0108 mM Helicobacter pylori N-trans-caffeoyltyramine