Crystallization (Comment) | Organism |
---|---|
vapour diffusion method. Crystallization of protein and protein-inhibitor complexes with N-formyl-H-hydroxy-3-phenylpropylamine, N-hydroxy-N-[3-(6-methyl pyridine-2-yl)propyl] formamide or N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | Staphylococcus aureus |
vapour diffusion method. Crystallization of protein and protein-inhibitor complexes with N-formyl-H-hydroxy-3-phenylpropylamine, N-hydroxy-N-[3-(6-methyl pyridine-2-yl)propyl] formamide or N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | Haemophilus influenzae |
vapour diffusion method. Crystallization of protein and protein-inhibitor complexes with N-formyl-H-hydroxy-3-phenylpropylamine, N-hydroxy-N-[3-(6-methyl pyridine-2-yl)propyl] formamide or N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | Escherichia coli |
vapour diffusion method. Crystallization of protein and protein-inhibitor complexes with N-formyl-H-hydroxy-3-phenylpropylamine, N-hydroxy-N-[3-(6-methyl pyridine-2-yl)propyl] formamide or N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | Streptococcus pneumoniae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | i.e. SB 543668, IC50: 0.00115 mM | Escherichia coli | |
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | i.e. SB 543668, IC50: 0.00032 mM | Haemophilus influenzae | |
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | i.e. SB 543668, IC50: 0.0022 mM | Staphylococcus aureus | |
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | i.e. SB 543668, IC50: 0.0039 mM | Streptococcus pneumoniae | |
N-formyl-N-hydroxy-3-phenylpropylamine | i.e. SB 485345, IC50: 0.00016 mM | Escherichia coli | |
N-formyl-N-hydroxy-3-phenylpropylamine | i.e. SB 485345, IC50: 0.00015 mM | Haemophilus influenzae | |
N-formyl-N-hydroxy-3-phenylpropylamine | i.e. SB 485345, IC50: 0.00025 mM | Staphylococcus aureus | |
N-formyl-N-hydroxy-3-phenylpropylamine | i.e. SB 485345, IC50: 0.0004 mM | Streptococcus pneumoniae | |
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | i.e. SB 505684, IC50: 0.0028 mM | Escherichia coli | |
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | i.e. SB 505684, IC50: 0.00104 mM | Haemophilus influenzae | |
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | i.e. SB 505684, IC50: 0.00109 mM | Staphylococcus aureus | |
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | i.e. SB 505684, IC50: 0.0022 mM | Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.6 | - |
formyl-Met-Ala-Ser | pH 7.6, 25°C | Staphylococcus aureus | |
4 | - |
formyl-Met-Ala-Ser | pH 7.6, 25°C | Streptococcus pneumoniae | |
4.8 | - |
formyl-Met-Ala-Ser | pH 7.6, 25°C | Haemophilus influenzae | |
9.1 | - |
formyl-Met-Ala-Ser | pH 7.6, 25°C | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-Met-Ala-Ser + H2O | - |
Staphylococcus aureus | formate + Met-Ala-Ser | - |
? | |
formyl-Met-Ala-Ser + H2O | - |
Haemophilus influenzae | formate + Met-Ala-Ser | - |
? | |
formyl-Met-Ala-Ser + H2O | - |
Escherichia coli | formate + Met-Ala-Ser | - |
? | |
formyl-Met-Ala-Ser + H2O | - |
Streptococcus pneumoniae | formate + Met-Ala-Ser | - |
? |
Synonyms | Comment | Organism |
---|---|---|
- |
Staphylococcus aureus | |
- |
Haemophilus influenzae | |
- |
Escherichia coli | |
- |
Streptococcus pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
103 | - |
formyl-Met-Ala-Ser | pH7.6, 25°C | Escherichia coli | |
152 | - |
formyl-Met-Ala-Ser | pH7.6, 25°C | Staphylococcus aureus | |
322 | - |
formyl-Met-Ala-Ser | pH7.6, 25°C | Haemophilus influenzae | |
332 | - |
formyl-Met-Ala-Ser | pH7.6, 25°C | Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
i.e. SB 485345, IC50: 0.00015 mM | Haemophilus influenzae | N-formyl-N-hydroxy-3-phenylpropylamine | |
0.00016 | - |
i.e. SB 485345, IC50: 0.00016 mM | Escherichia coli | N-formyl-N-hydroxy-3-phenylpropylamine | |
0.00025 | - |
i.e. SB 485345, IC50: 0.00025 mM | Staphylococcus aureus | N-formyl-N-hydroxy-3-phenylpropylamine | |
0.00032 | - |
i.e. SB 543668, IC50: 0.00032 mM | Haemophilus influenzae | N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | |
0.00104 | - |
i.e. SB 505684, IC50: 0.00104 mM | Haemophilus influenzae | N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | |
0.00109 | - |
i.e. SB 505684, IC50: 0.00109 mM | Staphylococcus aureus | N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide | |
0.00115 | - |
i.e. SB 543668, IC50: 0.00115 mM | Escherichia coli | N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | |
0.0022 | - |
i.e. SB 543668, IC50: 0.0022 mM | Staphylococcus aureus | N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine | |
0.0028 | - |
i.e. SB 505684, IC50: 0.0028 mM | Escherichia coli | N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide |