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Literature summary for 3.5.1.88 extracted from

  • Grant, S.K.; Green, B.G.; Kozarich, J.W.
    Inhibition and structure-activity studies of methionine hydroxamic acid derivatives with bacterial peptide deformylase (2001), Bioorg. Chem., 29, 211-222.
    View publication on PubMed
Search for more literature for 3.5.1.88

Inhibitors

Inhibitors Comment Organism Structure
additional information the results of the study may provide the basis for the design of more potent and selective deformylase inhibitors as potential antibacterial agents Escherichia coli
N-[4-(trifluoromethyl)benzoyl]-L-Met time-dependent inhibition of zinc and cobalt deformylase, inhibition of full-length Co-PDF is competitive Escherichia coli
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide time-dependent inhibition of zinc and cobalt deformylase Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1
-
 N-formyl-L-Met-L-Val truncated cobalt deformylase Escherichia coli
8
-
 N-formyl-L-Met-L-Val truncated zinc deformylase Escherichia coli
12.4
-
 N-formyl-L-Met-L-Val full-length cobalt deformylase Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formyl-L-methionine-polypeptide + H2O Escherichia coli posttranslational deformylation of N-formyl-Met-polypeptide formate + L-methionine-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-formyl-L-Met-L-Val + H2O
-
 Escherichia coli formate + L-Met-L-Val
-
 ?
N-formyl-L-Met-Val + H2O
-
 Escherichia coli formate + L-Met-Val
-
 ?
N-formyl-L-methionine-polypeptide + H2O posttranslational deformylation of N-formyl-Met-polypeptide Escherichia coli formate + L-methionine-polypeptide
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0116
-
 N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide truncated Zn-PDF Escherichia coli
0.0118
-
 N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide truncated Co-PDF Escherichia coli
0.03
-
 N-[4-(trifluoromethyl)benzoyl]-L-Met
-
 Escherichia coli
0.2
-
 N-[4-(trifluoromethyl)benzoyl]-L-methionyl hydrazide full-lenfth Co-PDF Escherichia coli